1tpt: Difference between revisions

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~~'''~~THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION~~'''~~

===THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION===

~~==Overview==~~

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~~The three~~-~~dimensional structure of thymidine phosphorylase from Escherichia coli has been determined at 2.8 A resolution using multiple~~-~~isomorphous-replacement techniques.~~ The ~~amino acid sequence deduced from~~ the ~~deoA DNA sequence is also reported. Thymidine phosphorylase exists in~~ the ~~crystal~~ as ~~an S-shaped dimer in which the subunits are related by a crystallographic 2-fold axis. Each subunit is composed of a small alpha-helical domain of six helices and a large alpha~~/~~beta domain~~. ~~The alpha/beta domain includes a six-stranded mixed beta-sheet and a four-stranded antiparallel beta-sheet~~. ~~The active site has been identified by difference Fourier analyses of the binding of thymine and thymidine and lies in a cavity between~~ the ~~small and large domains~~. ~~The central beta~~-~~sheet is splayed open to accommodate a putative phosphate~~-~~binding site which is probably occupied by a sulfate ion in the crystal.~~

The line below this paragraph, {{ABSTRACT_PUBMED_2199449}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 2199449 is the PubMed ID number.

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==About this Structure==

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[[Category: Walter, M R.]]

[[Category: Thymidine phosphorylase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 10~~:13:53 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:06:39 2008''

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-[[Image:1tpt.jpg|left|200px]]
+{{Seed}}
+[[Image:1tpt.png|left|200px]]
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 {{STRUCTURE_1tpt|  PDB=1tpt  |  SCENE=  }}
-'''THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION'''
+===THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION===
-==Overview==
+<!--
-The three-dimensional structure of thymidine phosphorylase from Escherichia coli has been determined at 2.8 A resolution using multiple-isomorphous-replacement techniques. The amino acid sequence deduced from the deoA DNA sequence is also reported. Thymidine phosphorylase exists in the crystal as an S-shaped dimer in which the subunits are related by a crystallographic 2-fold axis. Each subunit is composed of a small alpha-helical domain of six helices and a large alpha/beta domain. The alpha/beta domain includes a six-stranded mixed beta-sheet and a four-stranded antiparallel beta-sheet. The active site has been identified by difference Fourier analyses of the binding of thymine and thymidine and lies in a cavity between the small and large domains. The central beta-sheet is splayed open to accommodate a putative phosphate-binding site which is probably occupied by a sulfate ion in the crystal.
+The line below this paragraph, {{ABSTRACT_PUBMED_2199449}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 2199449 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_2199449}}
 ==About this Structure==
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 [[Category: Walter, M R.]]
 [[Category: Thymidine phosphorylase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:13:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:06:39 2008''