1tqf: Difference between revisions

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[[Image:1tqf.gif|left|200px]]
{{Seed}}
[[Image:1tqf.png|left|200px]]


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{{STRUCTURE_1tqf|  PDB=1tqf  |  SCENE=  }}  
{{STRUCTURE_1tqf|  PDB=1tqf  |  SCENE=  }}  


'''Crystal structure of human Beta secretase complexed with inhibitor'''
===Crystal structure of human Beta secretase complexed with inhibitor===




==Overview==
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A small molecule nonpeptide inhibitor of beta-secretase has been developed, and its binding has been defined through crystallographic determination of the enzyme-inhibitor complex. The molecule is shown to bind to the catalytic aspartate residues in an unprecedented manner in the field of aspartyl protease inhibition. Additionally, the complex reveals a heretofore unknown S(3) subpocket that is created by the inhibitor. This structure has served an important role in the design of newer beta-secretase inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_15566281}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15566281 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15566281}}


==About this Structure==
==About this Structure==
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[[Category: Bace]]
[[Category: Bace]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:15:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:18:40 2008''
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