1ttn: Difference between revisions

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[[Image:1ttn.gif|left|200px]]
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[[Image:1ttn.png|left|200px]]


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{{STRUCTURE_1ttn|  PDB=1ttn  |  SCENE=  }}  
{{STRUCTURE_1ttn|  PDB=1ttn  |  SCENE=  }}  


'''Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells'''
===Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells===




==Overview==
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The previously identified dendritic cell-derived ubiquitin-like protein (DC-UbP) was implicated in cellular differentiation and apoptosis. Sequence alignment suggested that it contains a ubiquitin-like (UbL) domain in the C terminus. Here, we present the solution NMR structure and backbone dynamics of the UbL domain of DC-UbP. The overall structure of the domain is very similar to that of Ub despite low similarity (&lt;30%) in amino-acid sequence. One distinct feature of the domain structure is its highly positively charged surface that is different from the corresponding surfaces of the well-known UbL modifiers, Ub, NEDD8, and SUMO-1. The key amino-acid residues responsible for guiding polyubiquitinated proteins to proteasome degradation in Ub are not conserved in the UbL domain. This implies that the UbL domain of DC-UbP may have its own specific interaction partners with other yet unknown cellular functions related to the Ub pathway.
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{{ABSTRACT_PUBMED_15987890}}


==About this Structure==
==About this Structure==
1TTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTN OCA].  
1TTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTN OCA].  


==Reference==
==Reference==
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[[Category: Solution structure]]
[[Category: Solution structure]]
[[Category: Ubiquitin-like domain]]
[[Category: Ubiquitin-like domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:20:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:28:54 2008''

Revision as of 21:29, 27 July 2008

File:1ttn.png

Template:STRUCTURE 1ttn

Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells

Template:ABSTRACT PUBMED 15987890

About this Structure

1TTN is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells., Gao YG, Song AX, Shi YH, Chang YG, Liu SX, Yu YZ, Cao XT, Lin DH, Hu HY, Protein Sci. 2005 Aug;14(8):2044-50. Epub 2005 Jun 29. PMID:15987890

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