8zhw: Difference between revisions
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==Structure of Mokola lyssavirus glycoprotein in post-fusion state== | |||
<StructureSection load='8zhw' size='340' side='right'caption='[[8zhw]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8zhw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mokola_lyssavirus Mokola lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZHW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.199Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zhw OCA], [https://pdbe.org/8zhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zhw RCSB], [https://www.ebi.ac.uk/pdbsum/8zhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zhw ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLYCO_MOKV GLYCO_MOKV] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mokola lyssavirus]] | |||
[[Category: Lin S]] | |||
[[Category: Lu GW]] | |||
[[Category: Yang FL]] | |||
[[Category: Yang J]] | |||
[[Category: Ye F]] | |||
Latest revision as of 06:24, 5 February 2025
Structure of Mokola lyssavirus glycoprotein in post-fusion state
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