1tv9: Difference between revisions

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[[Image:1tv9.gif|left|200px]]
{{Seed}}
[[Image:1tv9.png|left|200px]]


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{{STRUCTURE_1tv9|  PDB=1tv9  |  SCENE=  }}  
{{STRUCTURE_1tv9|  PDB=1tv9  |  SCENE=  }}  


'''HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE'''
===HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE===




==Overview==
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DNA polymerases generally select the correct nucleotide from a pool of structurally similar molecules to preserve Watson-Crick base-pairing rules. We report the structure of DNA polymerase beta with DNA mismatches situated in the polymerase active site. This was achieved by using nicked product DNA that traps the mispair (template-primer, A-C or T-C) in the nascent base pair binding pocket. The structure of each mispair complex indicates that the bases do not form hydrogen bonds with one another, but form a staggered arrangement where the bases of the mispair partially overlap. This prevents closure/opening of the N subdomain that is believed to be required for catalytic cycling. The partially open conformation of the N subdomain results in distinct hydrogen bonding networks that are unique for each mispair. These structures define diverse molecular aspects of misinsertion that are consistent with the induced-fit model for substrate specificity.
The line below this paragraph, {{ABSTRACT_PUBMED_15458631}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15458631}}


==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleotidyltransferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:24:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:29:38 2008''

Revision as of 13:29, 28 July 2008

File:1tv9.png

Template:STRUCTURE 1tv9

HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE

Template:ABSTRACT PUBMED 15458631

About this Structure

1TV9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity., Krahn JM, Beard WA, Wilson SH, Structure. 2004 Oct;12(10):1823-32. PMID:15458631

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