1tw7: Difference between revisions

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[[Image:1tw7.gif|left|200px]]
{{Seed}}
[[Image:1tw7.png|left|200px]]


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{{STRUCTURE_1tw7|  PDB=1tw7  |  SCENE=  }}  
{{STRUCTURE_1tw7|  PDB=1tw7  |  SCENE=  }}  


'''Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target'''
===Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target===




==Overview==
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This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 A resolution in the absence of any inhibitor. This protease variant contains codon mutations at positions 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90 that confer resistance to protease inhibitors. Major differences between the wild-type and the variant include a structural change initiated by the M36V mutation and amplified by additional mutations in the flaps of the protease, resulting in a "wide-open" structure that represents an opening that is 8 A wider than the "open" structure of the wild-type protease. A second structural change is triggered by the L90M mutation that results in reshaping the 23-32 segment. A third key structural change of the protease is due to the mutations from longer to shorter amino acid side chains at positions 82 and 84.
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{{ABSTRACT_PUBMED_16338417}}


==About this Structure==
==About this Structure==
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[[Category: Multi-drug resistance]]
[[Category: Multi-drug resistance]]
[[Category: Polyprotein]]
[[Category: Polyprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:26:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:39:57 2008''

Revision as of 03:40, 29 July 2008

File:1tw7.png

Template:STRUCTURE 1tw7

Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target

Template:ABSTRACT PUBMED 16338417

About this Structure

1TW7 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target., Martin P, Vickrey JF, Proteasa G, Jimenez YL, Wawrzak Z, Winters MA, Merigan TC, Kovari LC, Structure. 2005 Dec;13(12):1887-95. PMID:16338417

Page seeded by OCA on Tue Jul 29 06:39:57 2008

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