1txm: Difference between revisions

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[[Image:1txm.gif|left|200px]]
{{Seed}}
[[Image:1txm.png|left|200px]]


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{{STRUCTURE_1txm|  PDB=1txm  |  SCENE=  }}  
{{STRUCTURE_1txm|  PDB=1txm  |  SCENE=  }}  


'''SCORPION TOXIN (MAUROTOXIN) FROM SCORPIO MAURUS, NMR, 35 STRUCTURES'''
===SCORPION TOXIN (MAUROTOXIN) FROM SCORPIO MAURUS, NMR, 35 STRUCTURES===




==Overview==
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Maurotoxin (MTX), purified from the scorpionid Scorpio maurus is a potent ligand for potassium channels. It shows a broad specificity as being active on Kv1.1 (Kd = 37 nM), Kv1.2 (Kd = 0.8 nM), Kv1.3 (Kd = 150 nM) voltage-gated potassium channels, as well as on small-conductance calcium-activated potassium channels. It has a unique disulfide pairing among the scorpion toxins family. The solution structure of MTX has been determined by 2D-NMR techniques, which led to the full description of its 3D conformation: a bended helix from residues 6 to 16 connected by a loop to a two-stranded antiparallel beta sheet (residues 23 to 26 and 28 to 31). The interaction of MTX with the pore region of the Kv1.2 potassium channel has been modeled according to their charge anisotropy. The structure of MTX is similar to other short scorpion toxins despite its peculiar disulfide pairing. Its interaction with the Kv1.2 channel involves a dipole moment, which guides and orients the toxin onto the pore, toward the binding site, and which thus is responsible for the specificity.
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{{ABSTRACT_PUBMED_9365987}}


==About this Structure==
==About this Structure==
1TXM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Scorpio_maurus Scorpio maurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXM OCA].  
1TXM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Scorpio_maurus Scorpio maurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXM OCA].  


==Reference==
==Reference==
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[[Category: Scorpion]]
[[Category: Scorpion]]
[[Category: Toxin]]
[[Category: Toxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:29:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:43:24 2008''

Revision as of 18:43, 28 July 2008

File:1txm.png

Template:STRUCTURE 1txm

SCORPION TOXIN (MAUROTOXIN) FROM SCORPIO MAURUS, NMR, 35 STRUCTURES

Template:ABSTRACT PUBMED 9365987

About this Structure

1TXM is a Single protein structure of sequence from Scorpio maurus. Full experimental information is available from OCA.

Reference

Solution structure of maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage-gated potassium channels., Blanc E, Sabatier JM, Kharrat R, Meunier S, el Ayeb M, Van Rietschoten J, Darbon H, Proteins. 1997 Nov;29(3):321-33. PMID:9365987

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