1txu: Difference between revisions

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[[Image:1txu.~~jpg~~|left|200px]]

[[Image:1txu.png|left|200px]]

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~~'''~~Crystal Structure of the Vps9 Domain of Rabex-5~~'''~~

===Crystal Structure of the Vps9 Domain of Rabex-5===

~~==Overview==~~

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The ~~Rab5 GTPase~~, ~~an essential regulator of endocytosis and endosome biogenesis~~, ~~is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain. Here, we show that~~ the ~~catalytic core of~~ the ~~Rab GEF Rabex-5 has a tandem architecture consisting of a Vps9 domain stabilized by an indispensable helical bundle~~. ~~A family-wide analysis of Rab specificity demonstrates high selectivity for Rab5 subfamily GTPases~~. ~~Conserved exchange determinants map to a common surface of the Vps9 domain~~, ~~which recognizes invariant aromatic residues in~~ the switch regions of Rab GTPases and selects for the Rab5 subfamily by requiring a small nonacidic residue preceding a critical phenylalanine in the switch I region. These and other observations reveal unexpected similarity with the Arf exchange site in the Sec7 domain.

The line below this paragraph, {{ABSTRACT_PUBMED_15339665}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15339665 is the PubMed ID number.

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==About this Structure==

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[[Category: Rab5 guanine-nucleotide exchange factor,gef]]

[[Category: Vps9 domain]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:26:19 2008''

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-[[Image:1txu.jpg|left|200px]]
+{{Seed}}
+[[Image:1txu.png|left|200px]]
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 {{STRUCTURE_1txu|  PDB=1txu  |  SCENE=  }}
-'''Crystal Structure of the Vps9 Domain of Rabex-5'''
+===Crystal Structure of the Vps9 Domain of Rabex-5===
-==Overview==
+<!--
-The Rab5 GTPase, an essential regulator of endocytosis and endosome biogenesis, is activated by guanine-nucleotide exchange factors (GEFs) that contain a Vps9 domain. Here, we show that the catalytic core of the Rab GEF Rabex-5 has a tandem architecture consisting of a Vps9 domain stabilized by an indispensable helical bundle. A family-wide analysis of Rab specificity demonstrates high selectivity for Rab5 subfamily GTPases. Conserved exchange determinants map to a common surface of the Vps9 domain, which recognizes invariant aromatic residues in the switch regions of Rab GTPases and selects for the Rab5 subfamily by requiring a small nonacidic residue preceding a critical phenylalanine in the switch I region. These and other observations reveal unexpected similarity with the Arf exchange site in the Sec7 domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_15339665}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15339665 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15339665}}
 ==About this Structure==
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 [[Category: Rab5 guanine-nucleotide exchange factor,gef]]
 [[Category: Vps9 domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:30:02 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:26:19 2008''