1tzg: Difference between revisions

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[[Image:1tzg.gif|left|200px]]
{{Seed}}
[[Image:1tzg.png|left|200px]]


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{{STRUCTURE_1tzg|  PDB=1tzg  |  SCENE=  }}  
{{STRUCTURE_1tzg|  PDB=1tzg  |  SCENE=  }}  


'''Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41'''
===Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41===




==Overview==
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Broadly neutralizing monoclonal antibodies to HIV-1 are rare but invaluable for vaccine design. 4E10 is the broadest neutralizing antibody known and recognizes a contiguous and highly conserved epitope in the membrane-proximal region of gp41. The crystal structure of Fab 4E10 was determined at 2.2 A resolution in complex with a 13-residue peptide containing the gp41 core epitope (NWFDIT). The bound peptide adopts a helical conformation in which the key contact residues, TrpP672, PheP673, IleP675, and ThrP676, map to one face of the helix. The peptide binds in a hydrophobic pocket that may emulate its potential interaction with the host cell membrane. The long CDR H3 of the antibody extends beyond the bound peptide in an orientation that suggests that its apex could contact the viral membrane when 4E10 is bound to its membrane-proximal epitope. These structural insights should assist in the design of immunogens to elicit 4E10-like neutralizing responses.
The line below this paragraph, {{ABSTRACT_PUBMED_15723805}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15723805}}


==About this Structure==
==About this Structure==
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[[Category: Zwick, M B.]]
[[Category: Zwick, M B.]]
[[Category: Antibody-epitope complex]]
[[Category: Antibody-epitope complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:33:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:24:44 2008''

Revision as of 03:24, 28 July 2008

File:1tzg.png

Template:STRUCTURE 1tzg

Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41

Template:ABSTRACT PUBMED 15723805

About this Structure

Full crystallographic information is available from OCA.

Reference

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41., Cardoso RM, Zwick MB, Stanfield RL, Kunert R, Binley JM, Katinger H, Burton DR, Wilson IA, Immunity. 2005 Feb;22(2):163-73. PMID:15723805

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