9dn8: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9dn8 ~~is ON HOLD until Paper Publication~~

==RamR variant S2.3 complexed with 1S-1-phenyl-1,2,3,4-tetrahydroisoquinoline==

~~Authors~~: ~~Kim, W~~.~~, Zhang, Y~~.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[9dn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DN8 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9DN8 FirstGlance].

~~Description~~: ~~RamR variant S2.3 complexed with 1S~~-1-phenyl-1,2,3,4-tetrahydroisoquinoline

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BED:(1~{S})-1-phenyl-1,2,3,4-tetrahydroisoquinoline'>A1BED</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: Kim, W]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9dn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dn8 OCA], [https://pdbe.org/9dn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dn8 RCSB], [https://www.ebi.ac.uk/pdbsum/9dn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dn8 ProSAT]</td></tr>

[[Category: Zhang~~, Y.J~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/HTHTR_SALTY HTHTR_SALTY] Transcriptional regulator (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Represses the transcription of the transcriptional activator RamA and, thereby, leads to repression of the expression of the efflux pump subunits AcrA and AcrB, and TolC (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Acts by binding directly to the promoter region of the ramA gene (PubMed:22123696, PubMed:22948865, PubMed:23800819). Promoter binding may be inhibited partially by the small regulatory RNA StyR3, perhaps thereby ensuring a basal level of expression of RamA.[UniProtKB:A0A0H3GJQ8]<ref>PMID:18443112</ref> <ref>PMID:22123696</ref> <ref>PMID:22948865</ref> <ref>PMID:23800819</ref> <ref>PMID:30655545</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]

[[Category: Kim W]]

[[Category: Zhang YJ]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9dn8 is ON HOLD  until Paper Publication
+==RamR variant S2.3 complexed with 1S-1-phenyl-1,2,3,4-tetrahydroisoquinoline==
+<StructureSection load='9dn8' size='340' side='right'caption='[[9dn8]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
-Authors: Kim, W., Zhang, Y.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9dn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DN8 FirstGlance]. <br>
-Description: RamR variant S2.3 complexed with 1S-1-phenyl-1,2,3,4-tetrahydroisoquinoline
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BED:(1~{S})-1-phenyl-1,2,3,4-tetrahydroisoquinoline'>A1BED</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Kim, W]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dn8 OCA], [https://pdbe.org/9dn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dn8 RCSB], [https://www.ebi.ac.uk/pdbsum/9dn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dn8 ProSAT]</span></td></tr>
-[[Category: Zhang, Y.J]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HTHTR_SALTY HTHTR_SALTY] Transcriptional regulator (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Represses the transcription of the transcriptional activator RamA and, thereby, leads to repression of the expression of the efflux pump subunits AcrA and AcrB, and TolC (PubMed:18443112, PubMed:22948865, PubMed:23800819, PubMed:30655545). Acts by binding directly to the promoter region of the ramA gene (PubMed:22123696, PubMed:22948865, PubMed:23800819). Promoter binding may be inhibited partially by the small regulatory RNA StyR3, perhaps thereby ensuring a basal level of expression of RamA.[UniProtKB:A0A0H3GJQ8]<ref>PMID:18443112</ref> <ref>PMID:22123696</ref> <ref>PMID:22948865</ref> <ref>PMID:23800819</ref> <ref>PMID:30655545</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
+[[Category: Kim W]]
+[[Category: Zhang YJ]]