1u2m: Difference between revisions

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[[Image:1u2m.jpg|left|200px]]
{{Seed}}
[[Image:1u2m.png|left|200px]]


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{{STRUCTURE_1u2m|  PDB=1u2m  |  SCENE=  }}  
{{STRUCTURE_1u2m|  PDB=1u2m  |  SCENE=  }}  


'''Crystal Structure of Skp'''
===Crystal Structure of Skp===




==Overview==
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The Seventeen Kilodalton Protein (Skp) is a trimeric periplasmic chaperone that assists outer membrane proteins in their folding and insertion into membranes. Here we report the crystal structure of Skp from E. coli. The structure of the Skp trimer resembles a jellyfish with alpha-helical tentacles protruding from a beta barrel body defining a central cavity. The architecture of Skp is unexpectedly similar to that of Prefoldin/GimC, a cytosolic chaperone present in eukaria and archea, that binds unfolded substrates in its central cavity. The ability of Skp to prevent the aggregation of model substrates in vitro is independent of ATP. Skp can interact directly with membrane lipids and lipopolysaccharide (LPS). These interactions are needed for efficient Skp-assisted folding of membrane proteins. We have identified a putative LPS binding site on the outer surface of Skp and propose a model for unfolded substrate binding.
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{{ABSTRACT_PUBMED_15304217}}


==About this Structure==
==About this Structure==
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[[Category: Chaperone]]
[[Category: Chaperone]]
[[Category: Coiled coil]]
[[Category: Coiled coil]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:40:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:07:58 2008''

Revision as of 06:08, 29 July 2008

File:1u2m.png

Template:STRUCTURE 1u2m

Crystal Structure of Skp

Template:ABSTRACT PUBMED 15304217

About this Structure

1U2M is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Skp, a prefoldin-like chaperone that protects soluble and membrane proteins from aggregation., Walton TA, Sousa MC, Mol Cell. 2004 Aug 13;15(3):367-74. PMID:15304217

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