1xm9: Difference between revisions
New page: left|200px<br /> <applet load="1xm9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xm9, resolution 2.80Å" /> '''Structure of the ar... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1xm9.gif|left|200px]]<br /> | [[Image:1xm9.gif|left|200px]]<br /><applet load="1xm9" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1xm9" size=" | |||
caption="1xm9, resolution 2.80Å" /> | caption="1xm9, resolution 2.80Å" /> | ||
'''Structure of the armadillo repeat domain of plakophilin 1'''<br /> | '''Structure of the armadillo repeat domain of plakophilin 1'''<br /> | ||
==Overview== | ==Overview== | ||
The p120ctn subfamily of armadillo domain proteins has roles in modulating | The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins. | ||
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
1XM9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1XM9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM9 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 17: | Line 16: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Choi, H | [[Category: Choi, H J.]] | ||
[[Category: Weis, W | [[Category: Weis, W I.]] | ||
[[Category: armadillo repeat]] | [[Category: armadillo repeat]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:56:17 2008'' | ||
Revision as of 13:56, 21 February 2008
|
Structure of the armadillo repeat domain of plakophilin 1
Overview
The p120ctn subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120ctn subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins.
Disease
Known disease associated with this structure: Ectodermal dysplasia/skin fragility syndrome OMIM:[601975]
About this Structure
1XM9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the armadillo repeat domain of plakophilin 1., Choi HJ, Weis WI, J Mol Biol. 2005 Feb 11;346(1):367-76. Epub 2004 Dec 19. PMID:15663951
Page seeded by OCA on Thu Feb 21 15:56:17 2008
