1u3e: Difference between revisions

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[[Image:1u3e.gif|left|200px]]
{{Seed}}
[[Image:1u3e.png|left|200px]]


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{{STRUCTURE_1u3e|  PDB=1u3e  |  SCENE=  }}  
{{STRUCTURE_1u3e|  PDB=1u3e  |  SCENE=  }}  


'''DNA binding and cleavage by the HNH homing endonuclease I-HmuI'''
===DNA binding and cleavage by the HNH homing endonuclease I-HmuI===




==Overview==
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The structure of I-HmuI, which represents the last family of homing endonucleases without a defining crystallographic structure, has been determined in complex with its DNA target. A series of diverse protein structural domains and motifs, contacting sequential stretches of nucleotide bases, are distributed along the DNA target. I-HmuI contains an N-terminal domain with a DNA-binding surface found in the I-PpoI homing endonuclease and an associated HNH/N active site found in the bacterial colicins, and a C-terminal DNA-binding domain previously observed in the I-TevI homing endonuclease. The combination and exchange of these features between protein families indicates that the genetic mobility associated with homing endonucleases extends to the level of independent structural domains. I-HmuI provides an unambiguous structural connection between the His-Cys box endonucleases and the bacterial colicins, supporting the hypothesis that these enzymes diverged from a common ancestral nuclease.
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(as it appears on PubMed at http://www.pubmed.gov), where 15313606 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15313606}}


==About this Structure==
==About this Structure==
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[[Category: Hnh catalytic motif]]
[[Category: Hnh catalytic motif]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:42:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:47:48 2008''

Revision as of 13:47, 28 July 2008

File:1u3e.png

Template:STRUCTURE 1u3e

DNA binding and cleavage by the HNH homing endonuclease I-HmuI

Template:ABSTRACT PUBMED 15313606

About this Structure

1U3E is a Single protein structure of sequence from Bacillus phage spo1. Full crystallographic information is available from OCA.

Reference

DNA binding and cleavage by the HNH homing endonuclease I-HmuI., Shen BW, Landthaler M, Shub DA, Stoddard BL, J Mol Biol. 2004 Sep 3;342(1):43-56. PMID:15313606

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