1u40: Difference between revisions

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[[Image:1u40.gif|left|200px]]
{{Seed}}
[[Image:1u40.png|left|200px]]


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{{STRUCTURE_1u40|  PDB=1u40  |  SCENE=  }}  
{{STRUCTURE_1u40|  PDB=1u40  |  SCENE=  }}  


'''IspF with 4-diphosphocytidyl-2C-methyl-D-erythritol'''
===IspF with 4-diphosphocytidyl-2C-methyl-D-erythritol===




==Overview==
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Isoprenoids are biosynthesized from isopentenyl diphosphate and the isomeric dimethylallyl diphosphate via the mevalonate pathway or a mevalonate-independent pathway that was identified during the last decade. The non-mevalonate pathway is present in many bacteria, some algae and in certain protozoa such as the malaria parasite Plasmodium falciparum and in the plastids of higher plants, but not in mammals and archaea. Therefore, these enzymes have been recognised as promising drug targets. We report the crystal structure of Escherichia coli 2C- methyl-d-erythritol-2,4-cyclodiphosphate synthase (IspF), which converts 4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate into 2C-methyl-d-erythritol 2,4-cyclodiphosphate and CMP in a Mg-dependent reaction. The protein forms homotrimers that tightly bind one zinc ion per subunit at the active site, which helps to position the substrate for direct attack of the 2-phosphate group on the beta-phosphate.
The line below this paragraph, {{ABSTRACT_PUBMED_11829504}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11829504}}


==About this Structure==
==About this Structure==
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[[Category: Mep pathway]]
[[Category: Mep pathway]]
[[Category: Terpene biosynthesis]]
[[Category: Terpene biosynthesis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:44:13 2008''
 
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Revision as of 23:58, 28 July 2008

File:1u40.png

Template:STRUCTURE 1u40

IspF with 4-diphosphocytidyl-2C-methyl-D-erythritol

Template:ABSTRACT PUBMED 11829504

About this Structure

1U40 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids., Steinbacher S, Kaiser J, Wungsintaweekul J, Hecht S, Eisenreich W, Gerhardt S, Bacher A, Rohdich F, J Mol Biol. 2002 Feb 8;316(1):79-88. PMID:11829504

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