1u7t: Difference between revisions

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[[Image:1u7t.~~gif~~|left|200px]]

[[Image:1u7t.png|left|200px]]

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~~'''~~Crystal Structure of ABAD/HSD10 with a Bound Inhibitor~~'''~~

===Crystal Structure of ABAD/HSD10 with a Bound Inhibitor===

~~==Overview==~~

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The ~~enzyme 17beta-hydroxysteroid dehydrogenase type 10 (HSD10)~~, ~~also known as amyloid beta-peptide-binding alcohol dehydrogenase (ABAD)~~, ~~has been implicated in~~ the ~~development of Alzheimer's disease. This protein, a member of~~ the ~~short-chain dehydrogenase~~/~~reductase family of enzymes, has been shown to bind beta-amyloid and to participate in beta-amyloid neurotoxicity~~. ~~We have determined the crystal structure of human ABAD/HSD10 complexed with NAD(+) and an inhibitory small molecule~~. ~~The inhibitor occupies the substrate-binding site and forms a covalent adduct with the NAD(+~~) ~~cofactor. The crystal structure provides a basis for the design of potent~~, ~~highly specific ABAD/HSD10 inhibitors with potential application in~~ the ~~treatment of Alzheimer's disease~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15342248}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15342248 is the PubMed ID number.

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==About this Structure==

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[[Category: Protein-inhibitor complex]]

[[Category: Rossmann fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3~~ 10:~~52:00~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:10:49 2008''

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-[[Image:1u7t.gif|left|200px]]
+{{Seed}}
+[[Image:1u7t.png|left|200px]]
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 {{STRUCTURE_1u7t|  PDB=1u7t  |  SCENE=  }}
-'''Crystal Structure of ABAD/HSD10 with a Bound Inhibitor'''
+===Crystal Structure of ABAD/HSD10 with a Bound Inhibitor===
-==Overview==
+<!--
-The enzyme 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), also known as amyloid beta-peptide-binding alcohol dehydrogenase (ABAD), has been implicated in the development of Alzheimer's disease. This protein, a member of the short-chain dehydrogenase/reductase family of enzymes, has been shown to bind beta-amyloid and to participate in beta-amyloid neurotoxicity. We have determined the crystal structure of human ABAD/HSD10 complexed with NAD(+) and an inhibitory small molecule. The inhibitor occupies the substrate-binding site and forms a covalent adduct with the NAD(+) cofactor. The crystal structure provides a basis for the design of potent, highly specific ABAD/HSD10 inhibitors with potential application in the treatment of Alzheimer's disease.
+The line below this paragraph, {{ABSTRACT_PUBMED_15342248}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15342248 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15342248}}
 ==About this Structure==
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 [[Category: Protein-inhibitor complex]]
 [[Category: Rossmann fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:52:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:10:49 2008''