1u7v: Difference between revisions

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[[Image:1u7v.jpg|left|200px]]
{{Seed}}
[[Image:1u7v.png|left|200px]]


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{{STRUCTURE_1u7v|  PDB=1u7v  |  SCENE=  }}  
{{STRUCTURE_1u7v|  PDB=1u7v  |  SCENE=  }}  


'''Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex'''
===Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex===




==Overview==
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The formation of protein complexes between phosphorylated R-Smads and Smad4 is a central event in the TGF-beta signaling pathway. We have determined the crystal structure of two R-Smad/Smad4 complexes, Smad3/Smad4 to 2.5 angstroms, and Smad2/Smad4 to 2.7 angstroms. Both complexes are heterotrimers, comprising two phosphorylated R-Smad subunits and one Smad4 subunit, a finding that was corroborated by isothermal titration calorimetry and mutational studies. Preferential formation of the R-Smad/Smad4 heterotrimer over the R-Smad homotrimer is largely enthalpy driven, contributed by the unique presence of strong electrostatic interactions within the heterotrimeric interfaces. The study supports a common mechanism of Smad protein assembly in TGF-beta superfamily signaling.
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{{ABSTRACT_PUBMED_15350224}}


==About this Structure==
==About this Structure==
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[[Category: Smad]]
[[Category: Smad]]
[[Category: Tgf-beta]]
[[Category: Tgf-beta]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:52:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:32:16 2008''

Revision as of 01:32, 29 July 2008

File:1u7v.png

Template:STRUCTURE 1u7v

Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex

Template:ABSTRACT PUBMED 15350224

About this Structure

1U7V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of heteromeric smad protein assembly in TGF-beta signaling., Chacko BM, Qin BY, Tiwari A, Shi G, Lam S, Hayward LJ, De Caestecker M, Lin K, Mol Cell. 2004 Sep 10;15(5):813-23. PMID:15350224

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