1xsp: Difference between revisions
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New page: left|200px<br /> <applet load="1xsp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xsp, resolution 2.20Å" /> '''Crystal Structure o... |
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[[Image:1xsp.gif|left|200px]]<br /> | [[Image:1xsp.gif|left|200px]]<br /><applet load="1xsp" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1xsp" size=" | |||
caption="1xsp, resolution 2.20Å" /> | caption="1xsp, resolution 2.20Å" /> | ||
'''Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate'''<br /> | '''Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate'''<br /> | ||
==Overview== | ==Overview== | ||
Pol lambda is a family X member believed to fill short gaps during DNA | Pol lambda is a family X member believed to fill short gaps during DNA repair. Here we report crystal structures of Pol lambda representing three steps in filling a single-nucleotide gap. These structures indicate that, unlike other DNA polymerases, Pol lambda does not undergo large subdomain movements during catalysis, and they provide a clear characterization of the geometry and stereochemistry of the in-line nucleotidyl transfer reaction. | ||
==About this Structure== | ==About this Structure== | ||
1XSP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NA and PPV as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] Full crystallographic information is available from [http:// | 1XSP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=PPV:'>PPV</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSP OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Bebenek, K.]] | [[Category: Bebenek, K.]] | ||
[[Category: Garcia-Diaz, M.]] | [[Category: Garcia-Diaz, M.]] | ||
[[Category: Krahn, J | [[Category: Krahn, J M.]] | ||
[[Category: Kunkel, T | [[Category: Kunkel, T A.]] | ||
[[Category: Pedersen, L | [[Category: Pedersen, L C.]] | ||
[[Category: NA]] | [[Category: NA]] | ||
[[Category: PPV]] | [[Category: PPV]] | ||
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[[Category: protein-dna complex]] | [[Category: protein-dna complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:58:18 2008'' | ||
