9jrt: Difference between revisions
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==Structural Insights into Selective Antagonism of TG6-129 and EP2 Prostaglandin Receptor== | |||
<StructureSection load='9jrt' size='340' side='right'caption='[[9jrt]], [[Resolution|resolution]] 3.28Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9jrt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JRT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.28Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EC5:~{N}-[[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]carbamothioyl]-3-(4-fluorophenyl)propanamide'>A1EC5</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jrt OCA], [https://pdbe.org/9jrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jrt RCSB], [https://www.ebi.ac.uk/pdbsum/9jrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jrt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/PE2R2_HUMAN PE2R2_HUMAN] Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Wu CR]] | |||
[[Category: Wu YL]] | |||
[[Category: Xu EH]] | |||
[[Category: Xu JY]] | |||
[[Category: Zhang H]] | |||
Latest revision as of 09:11, 22 October 2025
Structural Insights into Selective Antagonism of TG6-129 and EP2 Prostaglandin Receptor
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