1ub4: Difference between revisions

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[[Image:1ub4.gif|left|200px]]
{{Seed}}
[[Image:1ub4.png|left|200px]]


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{{STRUCTURE_1ub4|  PDB=1ub4  |  SCENE=  }}  
{{STRUCTURE_1ub4|  PDB=1ub4  |  SCENE=  }}  


'''crystal structure of MazEF complex'''
===crystal structure of MazEF complex===




==Overview==
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A structure of the Escherichia coli chromosomal MazE/MazF addiction module has been determined at 1.7 A resolution. Addiction modules consist of stable toxin and unstable antidote proteins that govern bacterial cell death. MazE (antidote) and MazF (toxin) form a linear heterohexamer composed of alternating toxin and antidote homodimers (MazF(2)-MazE(2)-MazF(2)). The MazE homodimer contains a beta barrel from which two extended C termini project, making interactions with flanking MazF homodimers that resemble the plasmid-encoded toxins CcdB and Kid. The MazE/MazF heterohexamer structure documents that the mechanism of antidote-toxin recognition is common to both chromosomal and plasmid-borne addiction modules, and provides general molecular insights into toxin function, antidote degradation in the absence of toxin, and promoter DNA binding by antidote/toxin complexes.
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{{ABSTRACT_PUBMED_12718874}}


==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:09:05 2008''

Revision as of 18:09, 28 July 2008

File:1ub4.png

Template:STRUCTURE 1ub4

crystal structure of MazEF complex

Template:ABSTRACT PUBMED 12718874

About this Structure

1UB4 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition., Kamada K, Hanaoka F, Burley SK, Mol Cell. 2003 Apr;11(4):875-84. PMID:12718874

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