1ucb: Difference between revisions

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[[Image:1ucb.gif|left|200px]]
{{Seed}}
[[Image:1ucb.png|left|200px]]


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{{STRUCTURE_1ucb|  PDB=1ucb  |  SCENE=  }}  
{{STRUCTURE_1ucb|  PDB=1ucb  |  SCENE=  }}  


'''STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ)'''
===STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ)===




==Overview==
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The X-ray structure of the uncomplexed human chimeric Fab' of the anti-tumor antibody BR96 has been determined at 2.6 A resolution. The structure has been compared with Lewis Y antigen-complexed structures of BR96 which were determined previously. The comparison reveals segmental motions and/or conformational rearrangements of three CDR loops (L1, L3, and H2), whereas CDR H3 does not undergo changes upon complexation despite its significant main-chain contacts to the carbohydrate antigen. In light of the uncomplexed chimeric Fab' structure reported here, the previously observed high mobility of the CL:CH1 domains of the complexed chimeric BR96 Fab is rationalized as a "swinging" motion approximately about the axis of the elbow bend.
The line below this paragraph, {{ABSTRACT_PUBMED_8683596}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8683596 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8683596}}


==About this Structure==
==About this Structure==
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[[Category: Fab]]
[[Category: Fab]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:01:56 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:38:09 2008''

Revision as of 04:38, 28 July 2008

File:1ucb.png

Template:STRUCTURE 1ucb

STRUCTURE OF UNCOMPLEXED FAB COMPARED TO COMPLEX (1CLY, 1CLZ)

Template:ABSTRACT PUBMED 8683596

About this Structure

1UCB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structure of the uncomplexed anti-tumor antibody BR96 and comparison with its antigen-bound form., Sheriff S, Chang CY, Jeffrey PD, Bajorath J, J Mol Biol. 1996 Jun 28;259(5):938-46. PMID:8683596

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