1ufj: Difference between revisions

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[[Image:1ufj.~~gif~~|left|200px]]

[[Image:1ufj.png|left|200px]]

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~~'''~~Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin~~'''~~

===Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin===

~~==Overview==~~

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~~Apo~~-~~myoglobin (apo~~-~~Mb) and apo-A71GMb were successfully reconstituted with FeIII(salophen) (1) (salophen = N~~,~~N'-bis(salicylidene)-1,2-phenilenediamine)~~, ~~Fe(III)(3,3'-Me2-salophen) (2), and FeIII(5,5'-t-Bu2-salophen) (3). The crystal structure of 2.apo-A71GMb shows~~ the ~~tight binding of~~ the ~~complex in the Mb cavity, while in wild-type apo-Mb~~ it ~~is highly disordered due to the steric repulsion with Ala71. Furthermore, the structure of 2~~.~~apo-A71GMb suggests a possible accommodation of a small substrate in the cavity~~. ~~In fact~~, the ~~cyanide association rate constant of 2~~.~~apo~~-~~A71GMb is 216~~-~~fold larger compared to that of 2.apo-Mb. These results provide us principles for the noncovalent fixation of synthetic metal cofactors at the desired positions in protein matrixes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15106972}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15106972 is the PubMed ID number.

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==About this Structure==

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[[Category: Salophen]]

[[Category: Schiff base]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:08:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:31:33 2008''

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-[[Image:1ufj.gif|left|200px]]
+{{Seed}}
+[[Image:1ufj.png|left|200px]]
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 {{STRUCTURE_1ufj|  PDB=1ufj  |  SCENE=  }}
-'''Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin'''
+===Crystal Structure of an Artificial Metalloprotein:Fe(III)(3,3'-Me2-salophen)/apo-A71G Myoglobin===
-==Overview==
+<!--
-Apo-myoglobin (apo-Mb) and apo-A71GMb were successfully reconstituted with FeIII(salophen) (1) (salophen = N,N'-bis(salicylidene)-1,2-phenilenediamine), Fe(III)(3,3'-Me2-salophen) (2), and FeIII(5,5'-t-Bu2-salophen) (3). The crystal structure of 2.apo-A71GMb shows the tight binding of the complex in the Mb cavity, while in wild-type apo-Mb it is highly disordered due to the steric repulsion with Ala71. Furthermore, the structure of 2.apo-A71GMb suggests a possible accommodation of a small substrate in the cavity. In fact, the cyanide association rate constant of 2.apo-A71GMb is 216-fold larger compared to that of 2.apo-Mb. These results provide us principles for the noncovalent fixation of synthetic metal cofactors at the desired positions in protein matrixes.
+The line below this paragraph, {{ABSTRACT_PUBMED_15106972}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15106972 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15106972}}
 ==About this Structure==
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 [[Category: Salophen]]
 [[Category: Schiff base]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:08:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:31:33 2008''