1uhy: Difference between revisions

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[[Image:1uhy.~~jpg~~|left|200px]]

[[Image:1uhy.png|left|200px]]

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~~'''~~Crystal structure of d(GCGATAGC): the base-intercalated duplex~~'''~~

===Crystal structure of d(GCGATAGC): the base-intercalated duplex===

~~==Overview==~~

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~~DNA fragments containing~~ the ~~sequence d(GCGAAAGC) prefer~~ to ~~adopt a base-intercalated~~ (~~zipper-like) duplex in the crystalline state~~. ~~To investigate effects of point mutation at the 5th residue on the structure, two crystal structures of d(GCGAGAGC) and d(GCGATAGC~~) ~~have been determined by X-ray crystallography. In the respective crystals~~, ~~the two octamers related by a crystallographic two-fold symmetry are aligned in an anti-parallel fashion and associated to each other to form a duplex, suggesting that the base-intercalated duplex~~ is ~~stable even when~~ the ~~5th residue is mutated with other bases~~. ~~The sheared G3:A6 pair formation makes the two phosphate backbones closer and facilitates formation of the A~~-X*-X-A* base-intercalated motif. The three duplexes are assembled around the three-fold axis, and their 3rd and 4th residues are bound to the hexamine cobalt chloride. The central 5th residues are bound to another cation.

The line below this paragraph, {{ABSTRACT_PUBMED_14646150}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14646150 is the PubMed ID number.

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==About this Structure==

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[[Category: Dna]]

[[Category: Sheared g:a pair]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:15:26 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:18:11 2008''

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-[[Image:1uhy.jpg|left|200px]]
+{{Seed}}
+[[Image:1uhy.png|left|200px]]
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 {{STRUCTURE_1uhy|  PDB=1uhy  |  SCENE=  }}
-'''Crystal structure of d(GCGATAGC): the base-intercalated duplex'''
+===Crystal structure of d(GCGATAGC): the base-intercalated duplex===
-==Overview==
+<!--
-DNA fragments containing the sequence d(GCGAAAGC) prefer to adopt a base-intercalated (zipper-like) duplex in the crystalline state. To investigate effects of point mutation at the 5th residue on the structure, two crystal structures of d(GCGAGAGC) and d(GCGATAGC) have been determined by X-ray crystallography. In the respective crystals, the two octamers related by a crystallographic two-fold symmetry are aligned in an anti-parallel fashion and associated to each other to form a duplex, suggesting that the base-intercalated duplex is stable even when the 5th residue is mutated with other bases. The sheared G3:A6 pair formation makes the two phosphate backbones closer and facilitates formation of the A-X*-X-A* base-intercalated motif. The three duplexes are assembled around the three-fold axis, and their 3rd and 4th residues are bound to the hexamine cobalt chloride. The central 5th residues are bound to another cation.
+The line below this paragraph, {{ABSTRACT_PUBMED_14646150}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14646150 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14646150}}
 ==About this Structure==
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 [[Category: Dna]]
 [[Category: Sheared g:a pair]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:15:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:18:11 2008''