9e70: Difference between revisions

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'''Unreleased structure'''


The entry 9e70 is ON HOLD  until Paper Publication
==Human XRN1 with Adenosine-3',5'-Bisphosphate (pAp) Bound==
 
<StructureSection load='9e70' size='340' side='right'caption='[[9e70]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Lockbaum, G.J., Lynes, M.M., Sickmier, E.A., Grigoriu, S., Boriack-Sjodin, P.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9e70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9E70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9E70 FirstGlance]. <br>
Description: Human XRN1 with Adenosine-3'',5''-Bisphosphate (pAp) Bound
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Sickmier, E.A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9e70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9e70 OCA], [https://pdbe.org/9e70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9e70 RCSB], [https://www.ebi.ac.uk/pdbsum/9e70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9e70 ProSAT]</span></td></tr>
[[Category: Grigoriu, S]]
</table>
[[Category: Lockbaum, G.J]]
== Function ==
[[Category: Lynes, M.M]]
[https://www.uniprot.org/uniprot/XRN1_HUMAN XRN1_HUMAN] Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).[UniProtKB:P97789]<ref>PMID:18172165</ref>
[[Category: Boriack-Sjodin, P.A]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Boriack-Sjodin PA]]
[[Category: Grigoriu S]]
[[Category: Lockbaum GJ]]
[[Category: Lynes MM]]
[[Category: Sickmier EA]]
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