9h6w: Difference between revisions
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==Crystal structure of the Salmonella effector SspH1== | |||
<StructureSection load='9h6w' size='340' side='right'caption='[[9h6w]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9h6w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H6W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h6w OCA], [https://pdbe.org/9h6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h6w RCSB], [https://www.ebi.ac.uk/pdbsum/9h6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h6w ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: House | == Function == | ||
[[Category: Kennedy | [https://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | |||
[[Category: Esposito D]] | |||
[[Category: House D]] | |||
[[Category: Kennedy CR]] | |||
[[Category: Rittinger K]] | |||
Latest revision as of 05:31, 28 May 2025
Crystal structure of the Salmonella effector SspH1
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