1ul2: Difference between revisions

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[[Image:1ul2.jpg|left|200px]]
{{Seed}}
[[Image:1ul2.png|left|200px]]


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{{STRUCTURE_1ul2|  PDB=1ul2  |  SCENE=  }}  
{{STRUCTURE_1ul2|  PDB=1ul2  |  SCENE=  }}  


'''Solution Conformation of alpha-Conotoxin GIC'''
===Solution Conformation of alpha-Conotoxin GIC===




==Overview==
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Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the cone snail Conus geographus. Alpha-conotoxin GIC potently blocks the alpha3beta2 subtype of human nicotinic acetylcholine receptor, showing a high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution structure of alpha-conotoxin GIC by NMR spectroscopy. The structure of alpha-conotoxin GIC is well defined with backbone and heavy atom root mean square deviations (residues 2-16) of 0.53 A and 0.96 A respectively. Structure and surface comparison of alpha-conotoxin GIC with the other alpha4/7 subfamily conotoxins reveals unique structural aspects of alpha-conotoxin GIC. In particular, the structural comparison between alpha-conotoxins GIC and MII indicates molecular features that may confer their similar receptor specificity profile, as well as those that provide the unique binding characteristics of alpha-conotoxin GIC.
The line below this paragraph, {{ABSTRACT_PUBMED_14992691}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_14992691}}


==About this Structure==
==About this Structure==
1UL2 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA].  
1UL2 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL2 OCA].  


==Reference==
==Reference==
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[[Category: C-terminal amidation]]
[[Category: C-terminal amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
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