1ula: Difference between revisions

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[[Image:1ula.~~jpg~~|left|200px]]

[[Image:1ula.png|left|200px]]

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~~'''~~APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS~~'''~~

===APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS===

~~==Overview==~~

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~~Competitive inhibitors of~~ the ~~salvage pathway enzyme purine-nucleoside phosphorylase~~ (~~purine-nucleoside~~:~~orthophosphate ribosyltransferase, EC 2~~.4.~~2.1~~) ~~have been designed by using~~ the ~~three-dimensional structure of the enzyme as determined by x-ray crystallography~~. ~~The process was an iterative one that utilized interactive computer graphics, Monte Carlo~~-~~based conformational searching, energy minimization, and x~~-ray crystallography. The proposed compounds were synthesized and tested by an in vitro assay. Among the compounds designed and synthesized are the most potent competitive inhibitors of purine nucleoside phosphorylase thus far reported.

The line below this paragraph, {{ABSTRACT_PUBMED_1763067}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1763067 is the PubMed ID number.

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==About this Structure==

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[[Category: Stoeckler, J D.]]

[[Category: Pentosyltransferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:23:00 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:02:27 2008''

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-[[Image:1ula.jpg|left|200px]]
+{{Seed}}
+[[Image:1ula.png|left|200px]]
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 {{STRUCTURE_1ula|  PDB=1ula  |  SCENE=  }}
-'''APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS'''
+===APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS===
-==Overview==
+<!--
-Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one that utilized interactive computer graphics, Monte Carlo-based conformational searching, energy minimization, and x-ray crystallography. The proposed compounds were synthesized and tested by an in vitro assay. Among the compounds designed and synthesized are the most potent competitive inhibitors of purine nucleoside phosphorylase thus far reported.
+The line below this paragraph, {{ABSTRACT_PUBMED_1763067}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1763067 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1763067}}
 ==About this Structure==
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 [[Category: Stoeckler, J D.]]
 [[Category: Pentosyltransferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:23:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:02:27 2008''