9ecf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9ecf is ~~ON HOLD until Paper Publication~~

==Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 2)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9ecf]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ECF OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9ECF FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B81:(3ALPHA,8ALPHA,17BETA)-ANDROST-5-ENE-3,17-DIOL'>B81</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ecf OCA], [https://pdbe.org/9ecf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ecf RCSB], [https://www.ebi.ac.uk/pdbsum/9ecf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ecf ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Bruning JB]]

[[Category: Pederick JL]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ecf is ON HOLD  until Paper Publication
+==Crystal structure of the hERbeta LBD complexed with androstenediol and SRC 2-2 peptide (crystal form 2)==
+<StructureSection load='9ecf' size='340' side='right'caption='[[9ecf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ecf]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ECF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ECF FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B81:(3ALPHA,8ALPHA,17BETA)-ANDROST-5-ENE-3,17-DIOL'>B81</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ecf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ecf OCA], [https://pdbe.org/9ecf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ecf RCSB], [https://www.ebi.ac.uk/pdbsum/9ecf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ecf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bruning JB]]
+[[Category: Pederick JL]]