9k53: Difference between revisions
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==Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state ED2.1== | |||
<StructureSection load='9k53' size='340' side='right'caption='[[9k53]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9k53]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K53 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Chen | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k53 OCA], [https://pdbe.org/9k53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k53 RCSB], [https://www.ebi.ac.uk/pdbsum/9k53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k53 ProSAT]</span></td></tr> | ||
[[Category: Mao | </table> | ||
[[Category: Wu | == Function == | ||
[https://www.uniprot.org/uniprot/PRS7_HUMAN PRS7_HUMAN] The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.<ref>PMID:9295362</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen E]] | |||
[[Category: Mao Y]] | |||
[[Category: Wu Z]] | |||
Latest revision as of 08:06, 29 April 2026
Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state ED2.1
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