1unk: Difference between revisions

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[[Image:1unk.gif|left|200px]]
{{Seed}}
[[Image:1unk.png|left|200px]]


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{{STRUCTURE_1unk|  PDB=1unk  |  SCENE=  }}  
{{STRUCTURE_1unk|  PDB=1unk  |  SCENE=  }}  


'''STRUCTURE OF COLICIN E7 IMMUNITY PROTEIN'''
===STRUCTURE OF COLICIN E7 IMMUNITY PROTEIN===




==Overview==
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Site-specific cleavage of mRNA has been identified in vivo for the polycistronic colicin E7 operon (ColE7), which occurs between G and A nucleotides located at the Asp52 codon (GAT) of the immunity gene (ceiE7). In vitro, this specific cleavage occurs only in the presence of the ceiE7 gene product (ImmE7). The crystal structure of dimeric ImmE7 has been determined at 1.8 A resolution by X-ray crystallographic analysis. We found that several residues located at the interface of dimeric ImmE7 bear surprising resemblance to the active sites of some RNases. These results suggest that dimeric ImmE7 may possess a novel RNase activity that cleaves its own mRNA at a specific site and thus autoregulates translational expression of the downstream celE7 gene as well as degradation of the upstream ceaE7 mRNA.
The line below this paragraph, {{ABSTRACT_PUBMED_9135159}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9135159 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9135159}}


==About this Structure==
==About this Structure==
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[[Category: Immunity protein]]
[[Category: Immunity protein]]
[[Category: Rnase active site]]
[[Category: Rnase active site]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:28:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:50:52 2008''
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