9h8n: Difference between revisions
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==Structure of BmrA T123C-S428C reduced form (apo state)== | |||
<StructureSection load='9h8n' size='340' side='right'caption='[[9h8n]], [[Resolution|resolution]] 3.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9h8n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9H8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9H8N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.21Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9h8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9h8n OCA], [https://pdbe.org/9h8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9h8n RCSB], [https://www.ebi.ac.uk/pdbsum/9h8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9h8n ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BMRA_BACSU BMRA_BACSU] An efflux transporter able to transport Hoechst 33342, ethidium bromide, doxorubicin and a number of other drugs in vitro into inside out vesicles. The endogenous substrate is unknown. It has been suggested that NBD dimerization induced by ATP-binding causes a large conformational change responsible for substrate translocation (PubMed:18215075). Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).<ref>PMID:18215075</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bacillus subtilis]] | |||
[[Category: Large Structures]] | |||
[[Category: Di Cesare M]] | |||
[[Category: Hanssen E]] | |||
[[Category: Jault JM]] | |||
[[Category: Kaplan E]] | |||
[[Category: Orelle C]] | |||
[[Category: Valimehr S]] | |||
Latest revision as of 03:38, 14 May 2026
Structure of BmrA T123C-S428C reduced form (apo state)
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