1uns: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1uns.jpg|left|200px]]
{{Seed}}
[[Image:1uns.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1uns|  PDB=1uns  |  SCENE=  }}  
{{STRUCTURE_1uns|  PDB=1uns  |  SCENE=  }}  


'''IDENTIFICATION OF A SECONDARY ZINC-BINDING SITE IN STAPHYLOCOCCAL ENTEROTOXIN C2: IMPLICATIONS FOR SUPERANTIGEN RECOGNITION'''
===IDENTIFICATION OF A SECONDARY ZINC-BINDING SITE IN STAPHYLOCOCCAL ENTEROTOXIN C2: IMPLICATIONS FOR SUPERANTIGEN RECOGNITION===




==Overview==
<!--  
The previously determined crystal structure of the superantigen staphylococcal enterotoxin C2 (SEC2) showed binding of a single zinc ion located between the N- and C-terminal domains. Here we present the crystal structure of SEC2 determined to 2.0 A resolution in the presence of additional zinc. The structure revealed the presence of a secondary zinc-binding site close to the major histocompatibility complex (MHC)-binding site of the toxin and some 28 A away from the primary zinc-binding site of the toxin found in previous studies. T cell stimulation assays showed that varying the concentration of zinc ions present affected the activity of the toxin and we observed that high zinc concentrations considerably inhibited T cell responses. This indicates that SEC2 may have multiple modes of interaction with the immune system that are dependent on serum zinc levels. The potential role of the secondary zinc-binding site and that of the primary one in the formation of the TCR.SEC2.MHC complex are considered, and the possibility that zinc may regulate the activity of SEC2 as a toxin facilitating different T cell responses is discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_14559915}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14559915 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_14559915}}


==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Zinc-binding site]]
[[Category: Zinc-binding site]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:28:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:08:59 2008''

Revision as of 18:09, 27 July 2008

File:1uns.png

Template:STRUCTURE 1uns

IDENTIFICATION OF A SECONDARY ZINC-BINDING SITE IN STAPHYLOCOCCAL ENTEROTOXIN C2: IMPLICATIONS FOR SUPERANTIGEN RECOGNITION

Template:ABSTRACT PUBMED 14559915

About this Structure

1UNS is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2. Implications for superantigen recognition., Papageorgiou AC, Baker MD, McLeod JD, Goda SK, Manzotti CN, Sansom DM, Tranter HS, Acharya KR, J Biol Chem. 2004 Jan 9;279(2):1297-303. Epub 2003 Oct 14. PMID:14559915

Page seeded by OCA on Sun Jul 27 21:08:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1uns&oldid=667164"