1y91: Difference between revisions
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New page: left|200px<br /> <applet load="1y91" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y91, resolution 2.15Å" /> '''Crystal structure o... |
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[[Image:1y91.gif|left|200px]]<br /> | [[Image:1y91.gif|left|200px]]<br /><applet load="1y91" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1y91" size=" | |||
caption="1y91, resolution 2.15Å" /> | caption="1y91, resolution 2.15Å" /> | ||
'''Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor'''<br /> | '''Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor'''<br /> | ||
==Overview== | ==Overview== | ||
The protein structure guided design of a series of | The protein structure guided design of a series of pyrazolo[1,5-a]pyrimidines with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some examples were shown to inhibit the growth of human colon tumour cells, were equipotent for CDK1 and were selective against GSK-3beta and other kinases. | ||
==About this Structure== | ==About this Structure== | ||
1Y91 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CT9 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | 1Y91 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CT9:'>CT9</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y91 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bower, J | [[Category: Bower, J F.]] | ||
[[Category: Cansfield, A | [[Category: Cansfield, A D.]] | ||
[[Category: Dokurno, P.]] | [[Category: Dokurno, P.]] | ||
[[Category: Francis, G | [[Category: Francis, G L.]] | ||
[[Category: Hebdon, R | [[Category: Hebdon, R J.]] | ||
[[Category: Howes, R.]] | [[Category: Howes, R.]] | ||
[[Category: Jackson, P | [[Category: Jackson, P S.]] | ||
[[Category: Lockie, A | [[Category: Lockie, A M.]] | ||
[[Category: Moore, J | [[Category: Moore, J D.]] | ||
[[Category: Murray, J | [[Category: Murray, J B.]] | ||
[[Category: Nunns, C | [[Category: Nunns, C L.]] | ||
[[Category: Parratt, M | [[Category: Parratt, M J.]] | ||
[[Category: Powles, J.]] | [[Category: Powles, J.]] | ||
[[Category: Richardson, C | [[Category: Richardson, C M.]] | ||
[[Category: Robertson, A.]] | [[Category: Robertson, A.]] | ||
[[Category: Surgenor, A | [[Category: Surgenor, A E.]] | ||
[[Category: Torrance, C | [[Category: Torrance, C J.]] | ||
[[Category: Williamson, D | [[Category: Williamson, D S.]] | ||
[[Category: CT9]] | [[Category: CT9]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
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[[Category: serine/threonine protein kinase]] | [[Category: serine/threonine protein kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:02:56 2008'' | ||
