Semaglutide: Difference between revisions
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==Half-life== | ==Half-life== | ||
GLP-1 has a half-life of about two minutes in the bloodstream, and thus is unsuitable as medication unless administered continually. GLP-1 is initially degraded by dipeptidyl peptidase IV (DPP-4), a serine protease expressed on the surface of cells throughout the body<ref>PMID: 26284071</ref>. DPP-4 exists both as a membrane-bound enzyme and in a free form, released into circulation through a process called shedding. Like chymotrypsin, DPP-4 has a unique active site with a catalytic triad. Different from chymotrypsin, DPP-4 is an exoprotease, capable of recognizing and cleaving peptides with a proline or alanine residue in the second position, thus removing a dipeptide. | GLP-1 has a half-life of about two minutes in the bloodstream, and thus is unsuitable as medication unless administered continually. GLP-1 is initially degraded by dipeptidyl peptidase IV (DPP-4), a serine protease expressed on the surface of cells throughout the body<ref>PMID: 26284071</ref>. DPP-4 exists both as a membrane-bound enzyme and in a free form, released into circulation through a process called shedding. Like chymotrypsin, DPP-4 has a unique active site with a catalytic triad. Different from chymotrypsin, DPP-4 is an exoprotease, capable of recognizing and <scene name='10/1067195/Glp1_only/2'>cleaving</scene> peptides with a proline or alanine residue in the second position, thus removing a dipeptide. | ||
[[Image:GLP1 DPP4 processing.png|600px]] | [[Image:GLP1 DPP4 processing.png|600px]] | ||
