Semaglutide: Difference between revisions

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==Discovery==

Semaglutide was discovered <ref>PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid.

Semaglutide was discovered <ref name = "discovery">PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid.

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[[Image:GLP-1 semaglutide.png|700px]]

Bound to the GLP-1 receptor, the peptide forms a single <scene name='10/1062575/Semaglutide/1'>alpha helix</scene>, just like <scene name='10/1067195/Glp1_only/1'>GLP-1</scene>. Semaglutide interacts with the transmembrane and the extracellular portions of the <scene name='10/1062575/Semaglutide_and_receptor/1'>receptor</scene><ref>PMID: 34260945</ref>.

Bound to the GLP-1 receptor, the peptide forms a single <scene name='10/1062575/Semaglutide/1'>alpha helix</scene>, just like <scene name='10/1067195/Glp1_only/1'>GLP-1</scene>. Semaglutide interacts with the transmembrane and the extracellular portions of the <scene name='10/1062575/Semaglutide_and_receptor/1'>receptor</scene><ref>PMID: 34260945</ref><ref name="discovery"/>.

==Half-life==

Semaglutide: Difference between revisions

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@@ Line 5: / Line 5: @@
 ==Discovery==
-Semaglutide was discovered <ref>PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid.
+Semaglutide was discovered <ref name = "discovery">PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid.
 <StructureSection load='' size='340' side='right' caption='' scene='10/1062575/Semaglutide_and_receptor/2'>
@@ Line 13: / Line 13: @@
 [[Image:GLP-1 semaglutide.png|700px]]
-Bound to the GLP-1 receptor, the peptide forms a single <scene name='10/1062575/Semaglutide/1'>alpha helix</scene>, just like <scene name='10/1067195/Glp1_only/1'>GLP-1</scene>. Semaglutide interacts with the transmembrane and the extracellular portions of the <scene name='10/1062575/Semaglutide_and_receptor/1'>receptor</scene><ref>PMID: 34260945</ref>.
+Bound to the GLP-1 receptor, the peptide forms a single <scene name='10/1062575/Semaglutide/1'>alpha helix</scene>, just like <scene name='10/1067195/Glp1_only/1'>GLP-1</scene>. Semaglutide interacts with the transmembrane and the extracellular portions of the <scene name='10/1062575/Semaglutide_and_receptor/1'>receptor</scene><ref>PMID: 34260945</ref><ref name="discovery"/>.
 ==Half-life==