Semaglutide: Difference between revisions

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This page is under construction until Dec 20th 2024.
Semaglutide is an analog of the GLP-1 (glucagon-like peptide 1) hormone. It acts as an agonist to the GLP-1 receptor and is used as drug to manage diabetes. Its use has been growing as a weight-loss medication, and potential benefits across a wide range of diseases is currently studied.
Semaglutide is an analog of the GLP-1 (glucagon-like peptide 1) hormone. It acts as an agonist to the GLP-1 receptor and is used as drug to manage diabetes. Its use has been growing as a weight-loss medication, and potential benefits across a wide range of diseases is currently studied.


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Semaglutide was discovered <ref name = "discovery">PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid.
Semaglutide was discovered <ref name = "discovery">PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid.


==Structure and binding to GLP-1R==<StructureSection load='' size='340' side='right' caption='' scene='10/1062575/Semaglutide_and_receptor/2'>
==Structure and binding to GLP-1R==
<StructureSection load='' size='340' side='right' caption='' scene='10/1062575/Semaglutide_and_receptor/2'>
The primary structure of GLP-1 and of semaglutide are shown below. Semaglutide has a non-canonical amino acid in position 8 (corresponding to the second amino acid in the mature 7-37 peptide hormone). A fatty acid is attached is attached to the single lysine in semaglutide via a linker.
The primary structure of GLP-1 and of semaglutide are shown below. Semaglutide has a non-canonical amino acid in position 8 (corresponding to the second amino acid in the mature 7-37 peptide hormone). A fatty acid is attached is attached to the single lysine in semaglutide via a linker.


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