1urz: Difference between revisions

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[[Image:1urz.gif|left|200px]]
{{Seed}}
[[Image:1urz.png|left|200px]]


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{{STRUCTURE_1urz|  PDB=1urz  |  SCENE=  }}  
{{STRUCTURE_1urz|  PDB=1urz  |  SCENE=  }}  


'''LOW PH INDUCED, MEMBRANE FUSION CONFORMATION OF THE ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS'''
===LOW PH INDUCED, MEMBRANE FUSION CONFORMATION OF THE ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS===




==Overview==
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Enveloped viruses enter cells via a membrane fusion reaction driven by conformational changes of specific viral envelope proteins. We report here the structure of the ectodomain of the tick-borne encephalitis virus envelope glycoprotein, E, a prototypical class II fusion protein, in its trimeric low-pH-induced conformation. We show that, in the conformational transition, the three domains of the neutral-pH form are maintained but their relative orientation is altered. Similar to the postfusion class I proteins, the subunits rearrange such that the fusion peptide loops cluster at one end of an elongated molecule and the C-terminal segments, connecting to the viral transmembrane region, run along the sides of the trimer pointing toward the fusion peptide loops. Comparison with the low-pH-induced form of the alphavirus class II fusion protein reveals striking differences at the end of the molecule bearing the fusion peptides, suggesting an important conformational effect of the missing membrane connecting segment.
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{{ABSTRACT_PUBMED_14963486}}


==About this Structure==
==About this Structure==
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[[Category: Membrane fusion]]
[[Category: Membrane fusion]]
[[Category: Virus/viral protein]]
[[Category: Virus/viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:36:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:14:55 2008''

Revision as of 05:15, 28 July 2008

File:1urz.png

Template:STRUCTURE 1urz

LOW PH INDUCED, MEMBRANE FUSION CONFORMATION OF THE ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS

Template:ABSTRACT PUBMED 14963486

About this Structure

1URZ is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.

Reference

Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation., Bressanelli S, Stiasny K, Allison SL, Stura EA, Duquerroy S, Lescar J, Heinz FX, Rey FA, EMBO J. 2004 Feb 25;23(4):728-38. Epub 2004 Feb 12. PMID:14963486

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