1usx: Difference between revisions

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[[Image:1usx.gif|left|200px]]
{{Seed}}
[[Image:1usx.png|left|200px]]


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{{STRUCTURE_1usx|  PDB=1usx  |  SCENE=  }}  
{{STRUCTURE_1usx|  PDB=1usx  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE'''
===CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE===




==Overview==
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Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell fusion. Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface.
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{{ABSTRACT_PUBMED_15016893}}


==About this Structure==
==About this Structure==
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[[Category: Neuraminidase]]
[[Category: Neuraminidase]]
[[Category: Sialidase]]
[[Category: Sialidase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:38:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:15:43 2008''

Revision as of 20:15, 28 July 2008

File:1usx.png

Template:STRUCTURE 1usx

CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE

Template:ABSTRACT PUBMED 15016893

About this Structure

1USX is a Single protein structure of sequence from Newcastle disease virus. Full crystallographic information is available from OCA.

Reference

Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion., Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G, J Virol. 2004 Apr;78(7):3733-41. PMID:15016893

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