1utc: Difference between revisions

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[[Image:1utc.~~gif~~|left|200px]]

[[Image:1utc.png|left|200px]]

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~~'''~~CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT~~'''~~

===CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT===

~~==Overview==~~

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~~During the assembly of clathrin-coated vesicles~~, ~~many peripheral membrane proteins~~, ~~including~~ the ~~amphiphysins, use LLDLD-type clathrin-box motifs~~ to ~~interact with~~ the ~~N-terminal beta-propeller domain~~ (~~TD) of clathrin~~. ~~The 2~~.~~3 A-resolution structure of the clathrin TD in complex with a TLPWDLWTT peptide from amphiphysin 1 delineates a second clathrin-binding motif, PWXXW (the W box~~), ~~that binds at a site on~~ the ~~TD remote from the clathrin box-binding site~~. ~~The presence of both sequence motifs within the unstructured region of the amphiphysins allows them to bind more tightly to free TDs than do other endocytic proteins that contain only clathrin~~-~~box motifs. This property, along with the propensity of the N~~-~~terminal BAR domain to bind curved membranes, will preferentially localize amphiphysin and its partner, dynamin, to the periphery of invaginated clathrin lattices.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14981508}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14981508 is the PubMed ID number.

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==About this Structure==

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[[Category: Cytoskeleton]]

[[Category: Endocytosis]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:39:40 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:38:09 2008''

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-[[Image:1utc.gif|left|200px]]
+{{Seed}}
+[[Image:1utc.png|left|200px]]
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 {{STRUCTURE_1utc|  PDB=1utc  |  SCENE=  }}
-'''CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT'''
+===CLATHRIN TERMINAL DOMAIN COMPLEXED WITH TLPWDLWTT===
-==Overview==
+<!--
-During the assembly of clathrin-coated vesicles, many peripheral membrane proteins, including the amphiphysins, use LLDLD-type clathrin-box motifs to interact with the N-terminal beta-propeller domain (TD) of clathrin. The 2.3 A-resolution structure of the clathrin TD in complex with a TLPWDLWTT peptide from amphiphysin 1 delineates a second clathrin-binding motif, PWXXW (the W box), that binds at a site on the TD remote from the clathrin box-binding site. The presence of both sequence motifs within the unstructured region of the amphiphysins allows them to bind more tightly to free TDs than do other endocytic proteins that contain only clathrin-box motifs. This property, along with the propensity of the N-terminal BAR domain to bind curved membranes, will preferentially localize amphiphysin and its partner, dynamin, to the periphery of invaginated clathrin lattices.
+The line below this paragraph, {{ABSTRACT_PUBMED_14981508}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14981508 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14981508}}
 ==About this Structure==
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 [[Category: Cytoskeleton]]
 [[Category: Endocytosis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:39:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:38:09 2008''