9e0l: Difference between revisions
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The | ==The prefusion conformation of herpes simplex virus type 1 (HSV-1) glycoprotein B (gB)== | ||
<StructureSection load='9e0l' size='340' side='right'caption='[[9e0l]], [[Resolution|resolution]] 2.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9e0l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_F Human alphaherpesvirus 1 strain F]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9E0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9E0L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.19Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9e0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9e0l OCA], [https://pdbe.org/9e0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9e0l RCSB], [https://www.ebi.ac.uk/pdbsum/9e0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9e0l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GB_HHV11 GB_HHV11] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress (By similarity). Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).[HAMAP-Rule:MF_04032]<ref>PMID:15596825</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human alphaherpesvirus 1 strain F]] | |||
[[Category: Large Structures]] | |||
[[Category: Dai X]] | |||
[[Category: Mou Z]] | |||
[[Category: Wang S]] | |||
Latest revision as of 07:28, 19 March 2026
The prefusion conformation of herpes simplex virus type 1 (HSV-1) glycoprotein B (gB)
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