9l4l: Difference between revisions
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The entry | ==Structure of human SCMCcore complex contain NLRP2== | ||
<StructureSection load='9l4l' size='340' side='right'caption='[[9l4l]], [[Resolution|resolution]] 3.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9l4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L4L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l4l OCA], [https://pdbe.org/9l4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l4l RCSB], [https://www.ebi.ac.uk/pdbsum/9l4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l4l ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/NALP2_HUMAN NALP2_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NALP2_HUMAN NALP2_HUMAN] Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases.<ref>PMID:15456791</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Han Z]] | |||
[[Category: Jiao HZ]] | |||
[[Category: Li JH]] | |||
[[Category: Liu QT]] | |||
[[Category: Ou GJ]] | |||
Latest revision as of 05:54, 1 October 2025
Structure of human SCMCcore complex contain NLRP2
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