9mr5: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "9mr5" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cryo-EM structure of human OATP1C1 F240A mutant in complex with estrone 3-glucuronide== | |||
<StructureSection load='9mr5' size='340' side='right'caption='[[9mr5]], [[Resolution|resolution]] 3.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9mr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MR5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.13Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E3G:ESTRONE+BETA-D-GLUCURONIDE'>E3G</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mr5 OCA], [https://pdbe.org/9mr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mr5 RCSB], [https://www.ebi.ac.uk/pdbsum/9mr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mr5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SO1C1_HUMAN SO1C1_HUMAN] Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914).<ref>PMID:12351693</ref> <ref>PMID:18566113</ref> <ref>PMID:19129463</ref> <ref>PMID:30296914</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ge Y]] | |||
[[Category: Huang P]] | |||
[[Category: Jiang J]] | |||
[[Category: Yadav GP]] | |||
Latest revision as of 07:11, 16 July 2025
Cryo-EM structure of human OATP1C1 F240A mutant in complex with estrone 3-glucuronide
| ||||||||||||
