9ms1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9ms1 is ~~ON HOLD until Paper Publication~~

==Crystal structure of human CYP3A4 in complex with SJYHJ-111==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9ms1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MS1 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9MS1 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BNX:3-(2-chlorophenyl)-1-[(3-hydroxyphenyl)methyl]-1-[2-imidazol-1-yl-5-(trifluoromethyl)phenyl]urea'>A1BNX</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ms1 OCA], [https://pdbe.org/9ms1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ms1 RCSB], [https://www.ebi.ac.uk/pdbsum/9ms1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ms1 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chen T]]

[[Category: Jingheng W]]

[[Category: Miller DJ]]

[[Category: Nithianantham S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ms1 is ON HOLD  until Paper Publication
+==Crystal structure of human CYP3A4 in complex with SJYHJ-111==
+<StructureSection load='9ms1' size='340' side='right'caption='[[9ms1]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ms1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MS1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BNX:3-(2-chlorophenyl)-1-[(3-hydroxyphenyl)methyl]-1-[2-imidazol-1-yl-5-(trifluoromethyl)phenyl]urea'>A1BNX</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ms1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ms1 OCA], [https://pdbe.org/9ms1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ms1 RCSB], [https://www.ebi.ac.uk/pdbsum/9ms1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ms1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen T]]
+[[Category: Jingheng W]]
+[[Category: Miller DJ]]
+[[Category: Nithianantham S]]