9mpn: Difference between revisions

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'''Unreleased structure'''


The entry 9mpn is ON HOLD  until Paper Publication
==BRD3-BD1 A128T mutant==
 
<StructureSection load='9mpn' size='340' side='right'caption='[[9mpn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Patel, K., Mackay, J.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9mpn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9MPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9MPN FirstGlance]. <br>
Description: BRD3-BD1 A128T mutant
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9mpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9mpn OCA], [https://pdbe.org/9mpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9mpn RCSB], [https://www.ebi.ac.uk/pdbsum/9mpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9mpn ProSAT]</span></td></tr>
[[Category: Patel, K]]
</table>
[[Category: Mackay, J.P]]
== Disease ==
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
== Function ==
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mackay JP]]
[[Category: Patel K]]
Retrieved from "https://proteopedia.org/9mpn"