1ykb: Difference between revisions

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[[Image:1ykb.gif|left|200px]]<br />

[[Image:1ykb.gif|left|200px]]<br /><applet load="1ykb" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ykb" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ykb, resolution 2.60Å" />

'''Crystal Structure of Insect Cell Expressed IL-22'''<br />

==Overview==

The crystal structure of interleukin-22 expressed in Drosophila, melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution., IL-22(Dm) crystals contain six molecules in the asymmetric unit., Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in, Escherichia coli) structures reveals that N-linked glycosylation causes, only minor structural changes to the cytokine. However, 1-4 A main-chain, differences are observed between the six IL-22(Dm) monomers at regions, corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of, the carbohydrate and the conformational variation of IL22(Dm) provide new, insights into IL-22 receptor recognition.

The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.

==About this Structure==

1YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].

1YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Logsdon, N.J.]]

[[Category: Logsdon, N J.]]

[[Category: Walter, M.R.]]

[[Category: Walter, M R.]]

[[Category: Xu, T.]]

[[Category: NAG]]

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[[Category: interleukin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 20~~:21:~~19 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:18 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ykb.gif|left|200px]]<br />
+[[Image:1ykb.gif|left|200px]]<br /><applet load="1ykb" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ykb" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ykb, resolution 2.60&Aring;" />
 '''Crystal Structure of Insect Cell Expressed IL-22'''<br />
 ==Overview==
-The crystal structure of interleukin-22 expressed in Drosophila, melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution., IL-22(Dm) crystals contain six molecules in the asymmetric unit., Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in, Escherichia coli) structures reveals that N-linked glycosylation causes, only minor structural changes to the cytokine. However, 1-4 A main-chain, differences are observed between the six IL-22(Dm) monomers at regions, corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of, the carbohydrate and the conformational variation of IL22(Dm) provide new, insights into IL-22 receptor recognition.
+The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.
 ==About this Structure==
-YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].
+YKB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YKB OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Logsdon, N.J.]]
+[[Category: Logsdon, N J.]]
-[[Category: Walter, M.R.]]
+[[Category: Walter, M R.]]
 [[Category: Xu, T.]]
 [[Category: NAG]]
@@ Line 23: / Line 22: @@
 [[Category: interleukin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:21:19 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:06:18 2008''