1v1k: Difference between revisions

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[[Image:1v1k.gif|left|200px]]
{{Seed}}
[[Image:1v1k.png|left|200px]]


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{{STRUCTURE_1v1k|  PDB=1v1k  |  SCENE=  }}  
{{STRUCTURE_1v1k|  PDB=1v1k  |  SCENE=  }}  


'''CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR'''
===CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR===




==Overview==
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Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4.
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{{ABSTRACT_PUBMED_12941311}}


==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:58:21 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:16:37 2008''