9evj: Difference between revisions

Latest revision as of 08:04, 9 April 2025

Crystal Structure of human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1: complex with Mn2+ and UDP-Gal

Structural highlights

9evj is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Ligands:	CA, CL, GDU, MES, MN, NA, UDP
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

GT251_HUMAN Familial porencephaly. The disease is caused by variants affecting the gene represented in this entry.

Function

GT251_HUMAN Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317).^[1] ^[2] ^[3] ^[4]

References

↑ Schegg B, Hülsmeier AJ, Rutschmann C, Maag C, Hennet T. Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases. Mol Cell Biol. 2009 Feb;29(4):943-52. PMID:19075007 doi:10.1128/MCB.02085-07
↑ Perrin-Tricaud C, Rutschmann C, Hennet T. Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1. PLoS One. 2011;6(12):e29390. PMID:22216269 doi:10.1371/journal.pone.0029390
↑ Baumann S, Hennet T. Collagen Accumulation in Osteosarcoma Cells lacking GLT25D1 Collagen Galactosyltransferase. J Biol Chem. 2016 Aug 26;291(35):18514-24. PMID:27402836 doi:10.1074/jbc.M116.723379
↑ Miyatake S, Schneeberger S, Koyama N, Yokochi K, Ohmura K, Shiina M, Mori H, Koshimizu E, Imagawa E, Uchiyama Y, Mitsuhashi S, Frith MC, Fujita A, Satoh M, Taguri M, Tomono Y, Takahashi K, Doi H, Takeuchi H, Nakashima M, Mizuguchi T, Takata A, Miyake N, Saitsu H, Tanaka F, Ogata K, Hennet T, Matsumoto N. Biallelic COLGALT1 variants are associated with cerebral small vessel disease. Ann Neurol. 2018 Dec;84(6):843-853. PMID:30412317 doi:10.1002/ana.25367

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OCA

[1] Schegg B, Hülsmeier AJ, Rutschmann C, Maag C, Hennet T. Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases. Mol Cell Biol. 2009 Feb;29(4):943-52. PMID:19075007 doi:10.1128/MCB.02085-07

[2] Perrin-Tricaud C, Rutschmann C, Hennet T. Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1. PLoS One. 2011;6(12):e29390. PMID:22216269 doi:10.1371/journal.pone.0029390

[3] Baumann S, Hennet T. Collagen Accumulation in Osteosarcoma Cells lacking GLT25D1 Collagen Galactosyltransferase. J Biol Chem. 2016 Aug 26;291(35):18514-24. PMID:27402836 doi:10.1074/jbc.M116.723379

[4] Miyatake S, Schneeberger S, Koyama N, Yokochi K, Ohmura K, Shiina M, Mori H, Koshimizu E, Imagawa E, Uchiyama Y, Mitsuhashi S, Frith MC, Fujita A, Satoh M, Taguri M, Tomono Y, Takahashi K, Doi H, Takeuchi H, Nakashima M, Mizuguchi T, Takata A, Miyake N, Saitsu H, Tanaka F, Ogata K, Hennet T, Matsumoto N. Biallelic COLGALT1 variants are associated with cerebral small vessel disease. Ann Neurol. 2018 Dec;84(6):843-853. PMID:30412317 doi:10.1002/ana.25367

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9evj is ON HOLD  until Paper Publication
+==Crystal Structure of human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1: complex with Mn2+ and UDP-Gal==
+<StructureSection load='9evj' size='340' side='right'caption='[[9evj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9evj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EVJ FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDU:GALACTOSE-URIDINE-5-DIPHOSPHATE'>GDU</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9evj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9evj OCA], [https://pdbe.org/9evj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9evj RCSB], [https://www.ebi.ac.uk/pdbsum/9evj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9evj ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GT251_HUMAN GT251_HUMAN] Familial porencephaly. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/GT251_HUMAN GT251_HUMAN] Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836). By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836). Also involved in the biosynthesis of collagen type IV (PubMed:30412317).<ref>PMID:19075007</ref> <ref>PMID:22216269</ref> <ref>PMID:27402836</ref> <ref>PMID:30412317</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: De Marco M]]
+[[Category: Forneris F]]
+[[Category: Mattoteia D]]
+[[Category: Pinnola A]]
+[[Category: Rai SR]]
+[[Category: Scietti L]]

9evj: Difference between revisions

Latest revision as of 08:04, 9 April 2025

Crystal Structure of human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1: complex with Mn2+ and UDP-Gal

Structural highlights

Disease

Function

References

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