1v3n: Difference between revisions

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[[Image:1v3n.~~gif~~|left|200px]]

[[Image:1v3n.png|left|200px]]

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~~'''~~Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex~~'''~~

===Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex===

~~==Overview==~~

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~~Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases~~, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, ~~in which~~ the ~~eight G5 residues form a stacked double G-quartet in~~ the ~~central part~~. ~~At a higher K+ concentration, however, the octaplex is split into just two halves~~. ~~These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg~~), ~~according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of~~ the ~~repeats~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15133122}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15133122 is the PubMed ID number.

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==About this Structure==

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[[Category: Sheared g:a pair]]

[[Category: X-ray analysis]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:02:09 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:47:28 2008''

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-[[Image:1v3n.gif|left|200px]]
+{{Seed}}
+[[Image:1v3n.png|left|200px]]
 <!--
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 {{STRUCTURE_1v3n|  PDB=1v3n  |  SCENE=  }}
-'''Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex'''
+===Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex===
-==Overview==
+<!--
-Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats.
+The line below this paragraph, {{ABSTRACT_PUBMED_15133122}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15133122 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15133122}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Sheared g:a pair]]
 [[Category: X-ray analysis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:02:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:47:28 2008''