1yo8: Difference between revisions
New page: left|200px<br /> <applet load="1yo8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yo8, resolution 2.60Å" /> '''Strucuture of the C... |
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[[Image:1yo8.gif|left|200px]]<br /> | [[Image:1yo8.gif|left|200px]]<br /><applet load="1yo8" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''Strucuture of the C-terminal domain of human thrombospondin-2'''<br /> | '''Strucuture of the C-terminal domain of human thrombospondin-2'''<br /> | ||
==Overview== | ==Overview== | ||
Thrombospondins (THBSs) are secreted glycoproteins that have key roles in | Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2+) ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease. | ||
==About this Structure== | ==About this Structure== | ||
1YO8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1YO8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO8 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Annis, D | [[Category: Annis, D S.]] | ||
[[Category: Bernstein, D | [[Category: Bernstein, D A.]] | ||
[[Category: Carlson, C | [[Category: Carlson, C B.]] | ||
[[Category: Hannah, B | [[Category: Hannah, B A.]] | ||
[[Category: Keck, J | [[Category: Keck, J L.]] | ||
[[Category: Misenheimer, T | [[Category: Misenheimer, T M.]] | ||
[[Category: Mosher, D | [[Category: Mosher, D F.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: egf; ca(2+)-binding domains; lectin domain; disulfide]] | [[Category: egf; ca(2+)-binding domains; lectin domain; disulfide]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:07:27 2008'' | ||
Revision as of 14:07, 21 February 2008
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Strucuture of the C-terminal domain of human thrombospondin-2
Overview
Thrombospondins (THBSs) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2, which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module. These elements interact extensively to form three structural regions termed the stalk, wire and globe. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2+) ions and 18 disulfide bonds. The structure suggests how genetic alterations of THBSs result in disease.
About this Structure
1YO8 is a Single protein structure of sequence from Homo sapiens with NAG and CA as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the calcium-rich signature domain of human thrombospondin-2., Carlson CB, Bernstein DA, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL, Nat Struct Mol Biol. 2005 Oct;12(10):910-4. Epub 2005 Sep 25. PMID:16186819
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