9i0u: Difference between revisions
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==Structure of human PD-L1 in complex with clinically evaluated inhibitor== | |||
<StructureSection load='9i0u' size='340' side='right'caption='[[9i0u]], [[Resolution|resolution]] 1.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9i0u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I0U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IZJ:(5~{S})-5-[[[5-[2-chloranyl-3-[2-chloranyl-3-[6-methoxy-5-[[[(2~{S})-5-oxidanylidenepyrrolidin-2-yl]methylamino]methyl]pyrazin-2-yl]phenyl]phenyl]-3-methoxy-pyrazin-2-yl]methylamino]methyl]pyrrolidin-2-one'>A1IZJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i0u OCA], [https://pdbe.org/9i0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i0u RCSB], [https://www.ebi.ac.uk/pdbsum/9i0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i0u ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Magiera-Mularz | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Golebiowska-Mendroch K]] | |||
[[Category: Magiera-Mularz K]] | |||
[[Category: Plewka J]] | |||
[[Category: Slota A]] | |||
Latest revision as of 11:04, 18 June 2025
Structure of human PD-L1 in complex with clinically evaluated inhibitor
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