9i6v: Difference between revisions

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'''Unreleased structure'''


The entry 9i6v is ON HOLD  until Paper Publication
==14-3-3sigma binding to the ERa peptide and compound 40==
 
<StructureSection load='9i6v' size='340' side='right'caption='[[9i6v]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
Authors: Pennings, M.A.M., Arkin, M.R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9i6v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I6V FirstGlance]. <br>
Description: 14-3-3sigma binding to the ERa peptide and compound 40
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I0S:2-chloranyl-~{N}-[4-[3-[(2,6-dimethylphenyl)amino]imidazo[1,2-a]pyridin-2-yl]-3-fluoranyl-phenyl]ethanamide'>A1I0S</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
[[Category: Pennings, M.A.M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i6v OCA], [https://pdbe.org/9i6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i6v RCSB], [https://www.ebi.ac.uk/pdbsum/9i6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i6v ProSAT]</span></td></tr>
[[Category: Arkin, M.R]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arkin MR]]
[[Category: Pennings MAM]]
Retrieved from "https://proteopedia.org/9i6v"